Circulating advanced glycation end product levels in rats rapidly increase with acute renal failure
نویسندگان
چکیده
منابع مشابه
Paradox of circulating advanced glycation end product concentrations in patients with congestive heart failure and after heart transplantation.
OBJECTIVES To analyse circulating concentrations of advanced glycation end products (AGEs) in patients with severe congestive heart failure (CHF) and after heart transplantation; to identify the potential contribution of kidney function to plasma AGE concentrations; and to determine whether AGE concentrations and parameters of oxidative stress are interrelated. METHODS AND RESULTS Circulating...
متن کاملIncrease in the advanced glycation end product pentosidine in Bruch's membrane with age.
PURPOSE To determine whether there is an age-related increase of pentosidine in human Bruch's membranes and to localize pentosidine and carboxymethyllysine (CML), two well-characterized, advanced glycation end products (AGEs) in aged human Bruch's membranes and choroid in vivo. METHODS Human Bruch's membrane samples were isolated from the retinal pigment epithelium (RPE) and choroid and subje...
متن کاملIncreased Levels of Circulating Advanced Glycation End-Products in Menopausal Women with Osteoporosis
BACKGROUND Advanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing and diabetes. Increased levels of AGEs are found in the bone tissue of patients with osteoporosis. The purpose of this study was to evaluate circulating AGEs in patients with osteoporosis. METHODS We evaluated plasma AGEs, osteoporosis-related biomarkers, and bone mass in 82 menopausal women w...
متن کاملAdvanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake.
The slowly metabolized proteins of the extracellular matrix, typically collagen and elastin, accumulate reactive metabolites through uncontrolled non-enzymatic reactions such as glycation or the products arising from the reaction of unsaturated long chain fatty acid metabolites (possessing aldehydic groups). A typical example of these non-enzymatic changes is the formation of advanced glycation...
متن کاملThe role of autophagy in advanced glycation end product-induced proliferation and migration in rat vascular smooth muscle cells
Objective(s): To investigate the role of autophagy in advanced glycation end products (AGEs)-induced proliferation and migration in rat vascular smooth muscle cells (VSMCs).Materials and Methods: After culture, VSMCs were treated with 0, 1, 10, and 100 μg/ml concentrations of AGEs. Autophagy specific protein light chain 3 (LC3)-I/II was determined by western blotting, autophagosomes were observ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2001
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2001.59780058.x